|
KMID : 0545120020120060998
|
|
Journal of Microbiology and Biotechnology
2002 Volume.12 No. 6 p.998 ~ p.1001
|
|
|
Antitumor Activity of Lactobacillus plantarum Cytoplasm on Teratocarcinoma- Bearing Mice
|
|
KIM, JI YEON
WOO, HEE JONG/KIM, KYOUNG HEON/KIM, EUNG-RYOOL/JUNG, HOO-KIL/JUHN, HO-NAM/LEE, HYONG JOO
|
|
|
Abstract
|
|
|
|
Potential antitumor activity of Lactobacillus plantarum cytoplasm was examined using F9 teratocarcinoma-bearing BALB/c mice. The cytoplasmic fraction of L. plantarum was separated by sonication followed by ultracentrifugation. The fraction at a dose of 100 or 200 mg/kg/day was orally administered for 7 consecutive days before or after tumor inoculation to 16 mice. As a control, heat-killed whole cell was used at a dose of 100 mg/kg/day. Upon oral administrations of both the cytoplasm and heat-killed whole cell, when performed after and before tumor inoculation, the survival of F9-bearing mice prolonged more effectively. Administration of the cytoplasm after tumor inoculaion extended the average survival days by 30 and 40% or daily dosages of 100 and 200 mg/kg/day, respectively. This result suggests that the cytoplasmic fraction of L. plantarum has string antitumor activity against mouse F9 teratocarcinoma in vivo.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|